It was a pleasure to travel to Japan for the Sato Memorial International Award Lecture. I had a chance to see former group members and colleagues from Mitsui, Ono, and Daiichi Sankyo. I also got to see Koehler Lab posters from Keisuke Motoyama and Toshi Aiba.
This year the team enjoyed a round of mini golf to celebrate the hard work on glues, ‘TACs, novel probes and HTS twists. In the end, it’s all about having fun with your lab mates!
The High-Throughput Sciences team is building a platform for impactful, data-driven discovery. Solving complex biomedical questions takes more than just collecting more data—it requires innovative assays, novel study systems, and automated processes that produce consistent, high-quality results. Given the breadth of biomedical research, we often need custom solutions and infrastructure for unique samples, devices, and readouts. At HTS, we aim to democratize data production and analysis so we empower all researchers to extract meaningful insights. https://htslab.org/
Senior graduate student Jack Guo spoke about his work to develop MYC/FBXW7 molecular glues at the Koch Institute Retreat. It was a terrific retreat with many great presentations and productive collisions. Great chemistry is not just on paper but within the team at the Koch Institute. It was a day of convergence with many diverse scientists and engineers thinking about how to carve out new paths to impact cancer. Go Jack!
Chemical biology is what is due to the contributions of Stuart Schreiber, my PhD advisor from 1998-2003, and Peter Schultz. I’m thrilled that they shared this year’s Robert A. Welch Award. See the award video here: https://welch1.org/awards/welch-award-in-chemistry. Lots of cameos from chemical biologists, including yours truly. Also, see great a photo of new Professor Bocheng Wu hanging out with my dear collaborator Damian Young. Go Texas!
The Koehler Lab is fortunate to welcome our latest postdoc, Nacho Vergara from the Crews Lab at Yale! Of course, Nacho has quickly established himself as a powerful force in proximity induction, especially as it relates to tough targets underlying pediatric cancers.
Koehler Lab postdoc Bocheng Wu is flying the coop for a new faculty position at Texas State University! The team enjoyed on last lunch with Bocheng in Kendall Square. Don’t be a stranger and rock some great cowboy boots in Texas!
Congrats to Mo Toure for publishing his recent paper on CDK9 degradation in Cell Chemical Biology! Congrats to Raavi for her tour de force review of small molecules that modulate cytokines in Chemical Reviews!
The Koehler Lab aims to innovate in the earliest stages of drug discovery by building chemical tools or technologies to assist in the process of target validation and by expanding the repertoire of protein targets that are considered to be druggable. We focus primarily on building chemical tools and methods for studying temporal aspects of transcriptional regulation in development and disease with a focus on cancer.
The Koehler Lab is supported through the generosity of our public and private funding partners.
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