Koehler Headshot Serious Mark Ostow.jpg

Angela N. Koehler, PhD

Associate Professor, Department of Biological Engineering, MIT
Intramural Faculty, David H. Koch Institute for Integrative Cancer Research at MIT
Institute Member, Broad Institute of Harvard and MIT

koehler@mit.edu

Angela Koehler is the Goldblith Career Development Professor in Applied Biology in the Department of Biological Engineering at MIT and an intramural member of the David H. Koch Institute for Integrative Cancer Research at MIT. She is also an Institute Member of the Broad Institute and a Founding Member of the MIT Center for Precision Cancer Medicine. Her research group aims to discover and develop functional small-molecule probes of transcriptional regulators, including chromatin modifying enzymes and oncogenic transcription factors. Validated probes may be used to advance the understanding of transcription in development and disease. Selected probes may be developed into imaging agents, diagnostic tools, or therapeutic leads.

Angela received her B.A. in Biochemistry and Molecular Biology from Reed College in 1997. There she worked under the guidance of Professor Arthur Glasfeld on structural and biochemical studies of proteins that recognize tRNA or DNA. In 2003, she received her Ph.D. in Chemistry from Harvard University where she worked with Professor Stuart Schreiber to develop novel technologies for identifying and characterizing interactions between proteins and small molecules. Upon graduation, she became an Institute Fellow in the Chemical Biology Program at the Broad Institute and a Group Leader for the NCI Initiative for Chemical Genetics.


André Richters, PhD  Postdoctoral Associate    Education  PhD, Chemical Biology, Technische Universität Dortmund, Germany, 2013 MS, Chemical Biology, Technische Universität Dortmund, Germany, 2009 BS, Chemical Biology, Technische Universität Dortmund, Germany, 2007  Research Interests  My work in the Koehler lab involves the design, synthesis, and biological characterization of small molecule modulators and probes for studying Androgen Receptor splice variants in prostate cancer. In addition, I am interested in the development of bifunctional small molecule Lysosome Targeting Chimeras (LYTACs) to specifically induce lysosomal degradation of macromolecules including but not limited to proteins and protein complexes.  richters at mit.edu

André Richters, PhD
Postdoctoral Associate

Education
PhD, Chemical Biology, Technische Universität Dortmund, Germany, 2013
MS, Chemical Biology, Technische Universität Dortmund, Germany, 2009
BS, Chemical Biology, Technische Universität Dortmund, Germany, 2007
Research Interests
My work in the Koehler lab involves the design, synthesis, and biological characterization of small molecule modulators and probes for studying Androgen Receptor splice variants in prostate cancer. In addition, I am interested in the development of bifunctional small molecule Lysosome Targeting Chimeras (LYTACs) to specifically induce lysosomal degradation of macromolecules including but not limited to proteins and protein complexes.
richters at mit.edu

Andrew Chen  PHD Candidate,  Biological Engineering   Koch Institute Fellow, Cancer Research    Education  BS, Biological Engineering, Cornell University, 2011  Research Interests   The transcription factor c-Myc is a master regulator aberrant in ~70% of human cancers. My focus involves characterization of lead chemical probes for c-Myc or its major protein partner Max, and discovery of new small molecules that modulate c-Myc activity in specific contexts.   achen5 at mit.edu

Andrew Chen
PHD Candidate, Biological Engineering
Koch Institute Fellow, Cancer Research

Education
BS, Biological Engineering, Cornell University, 2011
Research Interests
The transcription factor c-Myc is a master regulator aberrant in ~70% of human cancers. My focus involves characterization of lead chemical probes for c-Myc or its major protein partner Max, and discovery of new small molecules that modulate c-Myc activity in specific contexts.
achen5 at mit.edu

Brice Curtin, PhD  Postdoctoral Associate    Education  PhD, Organic Chemistry, University of California, Los Angeles, 2017 BS, Chemistry, Missouri University of Science and Technology, 2012  Research Interests   I am interested in using synthetic organic chemistry and NMR to probe biological structure and mechanisms underpinning cancer.    bcurtin at mit.edu

Brice Curtin, PhD
Postdoctoral Associate

Education
PhD, Organic Chemistry, University of California, Los Angeles, 2017
BS, Chemistry, Missouri University of Science and Technology, 2012
Research Interests
I am interested in using synthetic organic chemistry and NMR to probe biological structure and mechanisms underpinning cancer.
bcurtin at mit.edu

Becky Leifer, MS  Research Associate    Education  MS, Biotechnology, Northeastern University, 2014 MS, Organic Chemistry, Northeastern University, 2005 BA, Chemistry, Vassar College, NY, 1998  Research Interests   I am interested in developing small-molecule probes that target deregulated transcription factors in cancer. This protein class has often been classified as "undruggable", however, with the use of unbiased binding assays such as SMM, we hope to find small molecules that modulate aberrant transcriptional activity.   beleifer at mit.edu

Becky Leifer, MS
Research Associate

Education
MS, Biotechnology, Northeastern University, 2014
MS, Organic Chemistry, Northeastern University, 2005
BA, Chemistry, Vassar College, NY, 1998
Research Interests
I am interested in developing small-molecule probes that target deregulated transcription factors in cancer. This protein class has often been classified as "undruggable", however, with the use of unbiased binding assays such as SMM, we hope to find small molecules that modulate aberrant transcriptional activity.
beleifer at mit.edu


Rob Wilson  PHD Candidate,  Biological Engineering   Education  BS, Biochemistry, Purdue University, 2015  Research Interests   I'm working to find small molecules to perturb oncogenic RAS signaling. I'm especially interested in discovering compounds that can act to destabilize target proteins through inducible ubiquitylation.   rwilsoN AT mit.edu

Rob Wilson
PHD Candidate, Biological Engineering

Education
BS, Biochemistry, Purdue University, 2015
Research Interests
I'm working to find small molecules to perturb oncogenic RAS signaling. I'm especially interested in discovering compounds that can act to destabilize target proteins through inducible ubiquitylation.
rwilsoN AT mit.edu

Catherine Henry  Graduate Student,  Biological Engineering   EDucation  BS, Biomedical Engineering, University of Virginia, 2016  Research Interests   I am interested in engineering high-throughput technologies to improve SMM screening for “undruggable” targets.   cchenry at mit.edu

Catherine Henry
Graduate Student, Biological Engineering

EDucation
BS, Biomedical Engineering, University of Virginia, 2016
Research Interests
I am interested in engineering high-throughput technologies to improve SMM screening for “undruggable” targets.
cchenry at mit.edu

Shelby (Pursley) Doyle   PhD Candidate,  Biological Engineering     NSF Graduate Research Fellow,  Ludwig Center for Molecular Oncology Graduate Fellow    education  BS, Biological Engineering, Louisiana State University, 2014  Research Interests   I am interested in understanding the role of certain transcription factors in both initiating and progressing disease in hormone-dependent prostate and breast cancer. Towards this goal, I am interested in developing small molecules that modulate these transcription factors as tools for Target and Biomarker Validation.   spursley at mit.edu

Shelby (Pursley) Doyle
PhD Candidate, Biological Engineering
NSF Graduate Research Fellow,
Ludwig Center for Molecular Oncology Graduate Fellow

education
BS, Biological Engineering, Louisiana State University, 2014
Research Interests
I am interested in understanding the role of certain transcription factors in both initiating and progressing disease in hormone-dependent prostate and breast cancer. Towards this goal, I am interested in developing small molecules that modulate these transcription factors as tools for Target and Biomarker Validation.
spursley at mit.edu

Nicholas   Struntz  , PhD   Postdoctoral Fellow   MIT-GSK Gertrude B. Elion Research Fellow,   Ludwig Center for Molecular Oncology Post-doctoral Fellow    Education  PhD, Medicinal Chemistry, University Minnesota, 2016 BS, Chemistry/ Biochemistry, University of Minnesota-Duluth, 2009  Research Interests   I am interested in discovering and characterizing small molecule binders of the Myc transcription factor, which is one of the most common oncogenic events in human cancer. I am also evaluating the mechanism of how these small molecules perturb Myc function.   nstruntz at mit.edu

Nicholas Struntz, PhD
Postdoctoral Fellow
MIT-GSK Gertrude B. Elion Research Fellow,
Ludwig Center for Molecular Oncology Post-doctoral Fellow

Education
PhD, Medicinal Chemistry, University Minnesota, 2016
BS, Chemistry/ Biochemistry, University of Minnesota-Duluth, 2009
Research Interests
I am interested in discovering and characterizing small molecule binders of the Myc transcription factor, which is one of the most common oncogenic events in human cancer. I am also evaluating the mechanism of how these small molecules perturb Myc function.
nstruntz at mit.edu


Yulong su  Postdoctoral Associate    Education  PhD in Cancer Biology, Oregon Health & Science University, 2017 BS in Biology, Shandong University, China, 2010  Research Interests   I am interested in using molecular tools to tease out the regulation of transcription factors MYC-MAX network as well as using SMM to discover chemical probes for key transcription factors in cancer. The long term goal is to develop novel strategies to rewire transcriptional programs for cancer treatment.    suy AT mit.edu

Yulong su
Postdoctoral Associate

Education
PhD in Cancer Biology, Oregon Health & Science University, 2017
BS in Biology, Shandong University, China, 2010
Research Interests
I am interested in using molecular tools to tease out the regulation of transcription factors MYC-MAX network as well as using SMM to discover chemical probes for key transcription factors in cancer. The long term goal is to develop novel strategies to rewire transcriptional programs for cancer treatment.
suy AT mit.edu

FLOrian Kabinger  Visiting Masters Student,  molecular Biotechnology, University of Applied Sciences, FH Campus Wien, Austria  Austrian Marshall Plan Foundation Fellow    education  BS, molecular Biotechnology, University of Applied Sciences, FH Campus Wien, Austria, 2017  Research Interests   I am interested in the opportunities of applying small molecules to target protein – protein interactions. In the context of oncogenic transcriptionAL networks, this aim might lead to the development of potent small molecule PRobes to validate untested therapeutic hypotheses.   kabinger AT MIT.EDU

FLOrian Kabinger
Visiting Masters Student, molecular Biotechnology, University of Applied Sciences, FH Campus Wien, Austria
Austrian Marshall Plan Foundation Fellow

education
BS, molecular Biotechnology, University of Applied Sciences, FH Campus Wien, Austria, 2017
Research Interests I am interested in the opportunities of applying small molecules to target protein – protein interactions. In the context of oncogenic transcriptionAL networks, this aim might lead to the development of potent small molecule PRobes to validate untested therapeutic hypotheses.
kabinger AT MIT.EDU

Julie urgiles  Medical student,  Harvard-MIT Health Sciences and Technology (hST)   Education  Chemistry, Cornell University, 2017  research interests  Target engagement studies of small molecule microarray hits for the treatment of castration-resistant prostate cancer  Julie_Urgiles AT hms.harvard.edu

Julie urgiles
Medical student, Harvard-MIT Health Sciences and Technology (hST)

Education
Chemistry, Cornell University, 2017
research interests
Target engagement studies of small molecule microarray hits for the treatment of castration-resistant prostate cancer
Julie_Urgiles AT hms.harvard.edu

 

 

High Throughput Screening Facility

Associates

Amedeo Vetere, PhD   Research Scientist ,   Wagner Laboratory   , Broad Institute   avetere at broadinstitute.org

Amedeo Vetere, PhD

Research Scientist, Wagner Laboratory, Broad Institute
avetere at broadinstitute.org

 
Jaime Cheah, PhD   Core Leader ,   HTS Facility    jcheah at mit.edu   Christian Soule   Lead Automation Engineer Specialist ,   HTS Facility    csoule at mit.edu

Jaime Cheah, PhD

Core Leader, HTS Facility
jcheah at mit.edu

Christian Soule

Lead Automation Engineer Specialist, HTS Facility
csoule at mit.edu